The Story of Redundant Catenins and Their Roles in Cell-cell Adhesion in the Liver
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چکیده
................................................................................................................................IV LIST OF TABLES....................................................................................................................XIV LIST OF FIGURES...................................................................................................................XV PREFACE ............................................................................................................................... XVII 1.0 INTRODUCTION ........................................................................................................ 1 1.1 β-CATENIN ......................................................................................................... 2 1.1.1 Wnt signaling ................................................................................................... 2 1.1.2 Adherens junction (AJ) ................................................................................... 5 1.2 β-CATENIN IN LIVER HOMEOSTASIS ........................................................ 7 1.3 β-CATENIN IN LIVER PATHOLOGIES ........................................................ 9 1.3.1 Targeting β-catenin in HCC ......................................................................... 10 1.4 HEPATOCYTE JUNCTIONS ......................................................................... 15 1.4.1 The blood-bile barrier ................................................................................... 16 1.4.2 Anchoring junctions (adherens junctions & desmosomes) ........................ 16 1.4.3 Occluding junctions (tight junctions) .......................................................... 19 1.4.4 Communicating junctions (gap junctions) .................................................. 20 1.5 JUNCTIONAL CROSS-TALK ........................................................................ 20 1.6 βVERSUS γ-CATENIN .................................................................................. 23
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